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NUCYNTA vs NUCYNTA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

~$342.56 /30
~$342.56 /30

Type

RX
RX

Active ingredient

TAPENTADOL HYDROCHLORIDE
TAPENTADOL HYDROCHLORIDE

Dosage forms

Tablet
Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 5 hours (terminal half-life, on average, after oral administration)
about 5 hours (terminal half-life, on average, after oral administration)

Treats

Pain
Pain

Frequently asked questions

Which is cheaper, Nucynta or Nucynta ER?

Pharmacies pay about the same to acquire either one — roughly $342.56 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Nucynta and Nucynta ER?

Both Nucynta and Nucynta ER share the active ingredient Tapentadol Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.