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NUCYNTA ER vs TAPENTADOL HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Rating

New
New

Pharmacy pays

~$335.93 /30
~$335.93 /30

Type

RX
RX

Active ingredient

TAPENTADOL HYDROCHLORIDE
TAPENTADOL HYDROCHLORIDE

Dosage forms

Tablet, extended release
Tablet

Drug class

Opioid Agonist
Opioid Agonist

Half-life

about 5 hours (terminal half-life, on average, after oral administration)
about 5 hours (terminal half-life, on average, after oral administration)

Treats

Pain
Pain

Frequently asked questions

Which is cheaper, Nucynta ER or Tapentadol Hydrochloride?

Pharmacies pay about the same to acquire either one — roughly $335.93 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Nucynta ER and Tapentadol Hydrochloride?

Both Nucynta ER and Tapentadol Hydrochloride share the active ingredient Tapentadol Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.