NUCYNTA ER vs SUBLIMAZE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. NUCYNTA ER and SUBLIMAZE PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NUCYNTA ER	SUBLIMAZE PRESERVATIVE FREE
Rating	New	72/100
Pharmacy pays	~$335.93 /30	$9.51 /mL
Type	RX	RX
Active ingredient	TAPENTADOL HYDROCHLORIDE	FENTANYL CITRATE
Manufacturer	Collegium Pharm Inc	Rising
Dosage forms	Tablet, extended release	Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 5 hours (terminal half-life, on average, after oral administration)	—
Treats	Pain	Pain

nucynta er sublimaze preservative free

Rating

New

72/100

Pharmacy pays

~$335.93 /30

$9.51 /mL

Type

Active ingredient

TAPENTADOL HYDROCHLORIDE

FENTANYL CITRATE

Manufacturer

Collegium Pharm Inc

Rising

Dosage forms

Tablet, extended release

Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 5 hours (terminal half-life, on average, after oral administration)

—

Treats

Pain

Frequently asked questions

What is the difference between Nucynta ER and Sublimaze Preservative Free?

Nucynta ER contains Tapentadol Hydrochloride, while Sublimaze Preservative Free contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.