NOXAFIL vs TOLSURA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. NOXAFIL and TOLSURA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NOXAFIL	TOLSURA
Rating	70/100	70/100
Pharmacy pays	~$74.63 /30	$0.84 /mL
Type	RX	RX
Active ingredient	POSACONAZOLE	ITRACONAZOLE
Manufacturer	Merck Sharp Dohme	Mayne Pharma
Dosage forms	Powder, Solution, Suspension, Tablet	Capsule
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	Boxed warning
Half-life	—	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.
Treats	Oral Candidiasis	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

noxafil tolsura

Rating

70/100

Pharmacy pays

~$74.63 /30

$0.84 /mL

Type

Active ingredient

POSACONAZOLE

ITRACONAZOLE

Manufacturer

Merck Sharp Dohme

Mayne Pharma

Dosage forms

Powder, Solution, Suspension, Tablet

Capsule

Drug class

Azole Antifungal

Boxed warning

None

Boxed warning

Half-life

—

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

Treats

Oral Candidiasis

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

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Frequently asked questions

Which is better-rated, Noxafil or Tolsura?

Noxafil and Tolsura are tied at 3.5 out of 5 by our independent rating.

What is the difference between Noxafil and Tolsura?

Noxafil contains Posaconazole, while Tolsura contains Itraconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.