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NOVAFED vs QOLIANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. NOVAFED and QOLIANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

novafedqoliana

Rating

70/100
68/100

Pharmacy pays

~$8.29 /30
$10.38 /mL

Type

RX
RX

Active ingredient

PSEUDOEPHEDRINE HYDROCHLORIDE
BRIMONIDINE TARTRATE

Manufacturer

Sanofi Aventis US
Sandoz

Dosage forms

Capsule, extended release
Solution

Drug class

Alpha-Adrenergic Agonist
Alpha-Adrenergic Agonist

Boxed warning

None
None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
—

Treats

Asthma, Common Cold, Perennial Allergic Rhinitis
Open-Angle Glaucoma

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Frequently asked questions

Which is better-rated, Novafed or Qoliana?

By our independent rating, Novafed scores higher — 3.5 vs 3.4 out of 5 for Qoliana. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Novafed and Qoliana?

Novafed contains Pseudoephedrine Hydrochloride, while Qoliana contains Brimonidine Tartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.