NORFLEX vs SKELAXIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. NORFLEX and SKELAXIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NORFLEX	SKELAXIN
Rating	New	New
Pharmacy pays	$0.48 /mL	~$11.97 /30
Type	RX	RX
Active ingredient	ORPHENADRINE CITRATE	METAXALONE
Manufacturer	Bausch	King Pharms LLC
Dosage forms	Tablet, extended release, Injectable	Tablet
Drug class	Muscle Relaxant	Muscle Relaxant
Boxed warning	None	None
Half-life	—	about 9 hours (terminal half-life 9.0 ± 4.8 hours after a 400 mg oral dose, fasted; ~8 hours at 800 mg)
Treats	Muscle Cramp, Muscle Rigidity, Myositis	Muscle Cramp, Muscle Rigidity, Muscle Spasticity

norflex skelaxin

Rating

New

Pharmacy pays

$0.48 /mL

~$11.97 /30

Type

Active ingredient

ORPHENADRINE CITRATE

METAXALONE

Manufacturer

Bausch

King Pharms LLC

Dosage forms

Tablet, extended release, Injectable

Tablet

Drug class

Muscle Relaxant

Boxed warning

None

Half-life

—

about 9 hours (terminal half-life 9.0 ± 4.8 hours after a 400 mg oral dose, fasted; ~8 hours at 800 mg)

Treats

Muscle Cramp, Muscle Rigidity, Myositis

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Frequently asked questions

What is the difference between Norflex and Skelaxin?

Norflex contains Orphenadrine Citrate, while Skelaxin contains Metaxalone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.