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NIZATIDINE vs PEPCID AC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Rating

70/100
70/100

Pharmacy pays

~$24.82 /30
~$1.54 /30

Type

RX
OTC

Active ingredient

NIZATIDINE
FAMOTIDINE

Dosage forms

Solution
Tablet

Drug class

Histamine-2 Receptor Antagonist
Histamine-2 Receptor Antagonist

Boxed warning

None
None

Half-life

2.5 to 3.5 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis
Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

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Frequently asked questions

Which is better-rated, Nizatidine or Pepcid Ac?

Nizatidine and Pepcid Ac are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Nizatidine or Pepcid Ac?

Pepcid Ac costs pharmacies less to acquire — about $1.54 vs $24.82 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Nizatidine and Pepcid Ac?

Nizatidine contains Nizatidine, while Pepcid Ac contains Famotidine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.