NEXIUM vs OMEPRAZOLE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. NEXIUM and OMEPRAZOLE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NEXIUM	OMEPRAZOLE
Rating	70/100	New
Pharmacy pays	—	~$1.52 /30
Type	RX	RX
Active ingredient	ESOMEPRAZOLE MAGNESIUM	OMEPRAZOLE
Manufacturer	Astrazeneca	Hetero Labs Ltd III
Dosage forms	Capsule, delayed release, Powder, delayed release	Capsule, Capsule, delayed release, Oral pellets, Tablet, delayed release, Tablet, orally disintegrating, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	—	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

nexium omeprazole

Rating

70/100

New

Pharmacy pays

—

~$1.52 /30

Type

Active ingredient

ESOMEPRAZOLE MAGNESIUM

OMEPRAZOLE

Manufacturer

Astrazeneca

Hetero Labs Ltd III

Dosage forms

Capsule, delayed release, Powder, delayed release

Capsule, Capsule, delayed release, Oral pellets, Tablet, delayed release, Tablet, orally disintegrating, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

—

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

What is the difference between Nexium and Omeprazole?

Nexium contains Esomeprazole Magnesium, while Omeprazole contains Omeprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.