NEXIUM vs NEXIUM 24HR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	NEXIUM	NEXIUM 24HR
Rating	70/100	70/100
Pharmacy pays	—	—
Type	RX	OTC
Active ingredient	ESOMEPRAZOLE MAGNESIUM	ESOMEPRAZOLE MAGNESIUM
Manufacturer	Astrazeneca	Astrazeneca LP
Dosage forms	Capsule, delayed release, Powder, delayed release	Capsule, delayed release, Tablet
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

nexium nexium 24hr

Rating

70/100

Pharmacy pays

—

Type

OTC

Active ingredient

ESOMEPRAZOLE MAGNESIUM

Manufacturer

Astrazeneca

Astrazeneca LP

Dosage forms

Capsule, delayed release, Powder, delayed release

Capsule, delayed release, Tablet

Drug class

Proton Pump Inhibitor

Boxed warning

None

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Get nexiumhigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Frequently asked questions

Which is better-rated, Nexium or Nexium 24hr?

Nexium and Nexium 24hr are tied at 3.5 out of 5 by our independent rating.

What is the difference between Nexium and Nexium 24hr?

Both Nexium and Nexium 24hr share the active ingredient Esomeprazole Magnesium, but Nexium is sold as RX and Nexium 24hr as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.