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NEXIUM 24HR vs ZANTAC 25

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Rating

70/100
New

Pharmacy pays

Type

OTC
RX

Active ingredient

ESOMEPRAZOLE MAGNESIUM
RANITIDINE HYDROCHLORIDE

Dosage forms

Capsule, delayed release, Tablet
Tablet, effervescent

Drug class

Proton Pump Inhibitor

Boxed warning

None
None

Half-life

about 2.5 to 3 hours

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux
Duodenal Ulcer, Peptic Esophagitis, Gastroesophageal Reflux

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

What is the difference between Nexium 24hr and Zantac 25?

Nexium 24hr contains Esomeprazole Magnesium, while Zantac 25 contains Ranitidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.