NEXIUM 24HR vs ZANTAC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	NEXIUM 24HR	ZANTAC
Rating	70/100	70/100
Pharmacy pays	—	—
Type	OTC	RX
Active ingredient	ESOMEPRAZOLE MAGNESIUM	RANITIDINE HYDROCHLORIDE
Manufacturer	Astrazeneca LP	Pai Holdings Pharm
Dosage forms	Capsule, delayed release, Tablet	Injectable, Syrup
Drug class	Proton Pump Inhibitor	—
Boxed warning	None	None
Half-life	—	about 2.5 to 3 hours
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Peptic Esophagitis, Gastroesophageal Reflux

nexium 24hr zantac

Rating

70/100

Pharmacy pays

—

Type

OTC

Active ingredient

ESOMEPRAZOLE MAGNESIUM

RANITIDINE HYDROCHLORIDE

Manufacturer

Astrazeneca LP

Pai Holdings Pharm

Dosage forms

Capsule, delayed release, Tablet

Injectable, Syrup

Drug class

Proton Pump Inhibitor

—

Boxed warning

None

Half-life

—

about 2.5 to 3 hours

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Duodenal Ulcer, Peptic Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Nexium 24hr or Zantac?

Nexium 24hr and Zantac are tied at 3.5 out of 5 by our independent rating.

What is the difference between Nexium 24hr and Zantac?

Nexium 24hr contains Esomeprazole Magnesium, while Zantac contains Ranitidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.