Skip to content
ppharmaranks
Menu
CompaniesProductsDrug classesConditionsBest by conditionTreatmentsInteraction checkerFood & medicinesWhat pharmacies payPill identifierMedicines & breastfeedingChildren’s dosage chartsDo medicines expire?Crushing & splitting pillsHow long meds take to workAlternating Tylenol & ibuprofenDrug recallsSupplementsSafety & lawsuitsGuidesA–ZHow we rate

NEXIUM 24HR vs PRILOSEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate
nexium 24hrprilosec

Rating

70/100
70/100

Pharmacy pays

—
~$1.52 /30

Type

OTC
RX

Active ingredient

ESOMEPRAZOLE MAGNESIUM
OMEPRAZOLE

Manufacturer

Astrazeneca LP
Astrazeneca

Dosage forms

Capsule, delayed release, Tablet
Powder, delayed release

Drug class

Proton Pump Inhibitor
Proton Pump Inhibitor

Boxed warning

None
None

Half-life

—
about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux
Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Get nexium 24hrhigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

Which is better-rated, Nexium 24hr or Prilosec?

Nexium 24hr and Prilosec are tied at 3.5 out of 5 by our independent rating.

What is the difference between Nexium 24hr and Prilosec?

Nexium 24hr contains Esomeprazole Magnesium, while Prilosec contains Omeprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.