NEXIUM 24HR vs OMEPRAZOLE MAGNESIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	NEXIUM 24HR	OMEPRAZOLE MAGNESIUM
Rating	70/100	68/100
Pharmacy pays	—	—
Type	OTC	RX
Active ingredient	ESOMEPRAZOLE MAGNESIUM	OMEPRAZOLE MAGNESIUM
Manufacturer	Astrazeneca LP	Aurobindo Pharma Ltd
Dosage forms	Capsule, delayed release, Tablet	Capsule, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	—	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

nexium 24hr omeprazole magnesium

Rating

70/100

68/100

Pharmacy pays

—

Type

OTC

Active ingredient

ESOMEPRAZOLE MAGNESIUM

OMEPRAZOLE MAGNESIUM

Manufacturer

Astrazeneca LP

Aurobindo Pharma Ltd

Dosage forms

Capsule, delayed release, Tablet

Capsule, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

—

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Nexium 24hr or Omeprazole Magnesium?

By our independent rating, Nexium 24hr scores higher — 3.5 vs 3.4 out of 5 for Omeprazole Magnesium. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Nexium 24hr and Omeprazole Magnesium?

Nexium 24hr contains Esomeprazole Magnesium, while Omeprazole Magnesium contains Omeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.