NEXICLON XR vs TIZANIDINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. NEXICLON XR and TIZANIDINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NEXICLON XR	TIZANIDINE HYDROCHLORIDE
Rating	New	New
Pharmacy pays	~$1.05 /30	~$1.00 /30
Type	RX	RX
Active ingredient	CLONIDINE	TIZANIDINE HYDROCHLORIDE
Manufacturer	Rosemont	Pharmobedient
Dosage forms	Tablet, extended release	Capsule, Tablet
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	None	None
Half-life	about 12 to 16 hours	about 2.5 hours
Treats	Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea	Muscle Cramp, Muscle Rigidity, Muscle Spasticity

nexiclon xr tizanidine hydrochloride

Rating

New

Pharmacy pays

~$1.05 /30

~$1.00 /30

Type

Active ingredient

CLONIDINE

TIZANIDINE HYDROCHLORIDE

Manufacturer

Rosemont

Pharmobedient

Dosage forms

Tablet, extended release

Capsule, Tablet

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

about 12 to 16 hours

about 2.5 hours

Treats

Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Get nexiclon xrhigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Frequently asked questions

Which is cheaper, Nexiclon XR or Tizanidine Hydrochloride?

Tizanidine Hydrochloride costs pharmacies less to acquire — about $1.00 vs $1.05 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Nexiclon XR and Tizanidine Hydrochloride?

Nexiclon XR contains Clonidine, while Tizanidine Hydrochloride contains Tizanidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.