NEORAL vs PROTOPIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. NEORAL and PROTOPIC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NEORAL	PROTOPIC
Rating	70/100	New
Pharmacy pays	~$52.85 /30	$0.65 /g
Type	RX	RX
Active ingredient	CYCLOSPORINE	TACROLIMUS
Manufacturer	Novartis	Leo Pharma As
Dosage forms	Capsule, Solution	Topical
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	Boxed warning	None
Half-life	about 8.4 hours (range 5 to 18 hours)	—
Treats	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus	Atopic Dermatitis, Graft Vs Host Disease

neoral protopic

Rating

70/100

New

Pharmacy pays

~$52.85 /30

$0.65 /g

Type

Active ingredient

CYCLOSPORINE

TACROLIMUS

Manufacturer

Novartis

Leo Pharma As

Dosage forms

Capsule, Solution

Topical

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

None

Half-life

about 8.4 hours (range 5 to 18 hours)

—

Treats

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

What is the difference between Neoral and Protopic?

Neoral contains Cyclosporine, while Protopic contains Tacrolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.