NEORAL vs PROGRAF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. NEORAL and PROGRAF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NEORAL	PROGRAF
Rating	70/100	72/100
Pharmacy pays	~$52.85 /30	$0.65 /g
Type	RX	RX
Active ingredient	CYCLOSPORINE	TACROLIMUS
Manufacturer	Novartis	Astellas
Dosage forms	Capsule, Solution	Capsule, Powder, Injectable
Drug class	Calcineurin Inhibitor Immunosuppressant	Calcineurin Inhibitor Immunosuppressant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 8.4 hours (range 5 to 18 hours)	—
Treats	Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus	Atopic Dermatitis, Graft Vs Host Disease

neoral prograf

Rating

70/100

72/100

Pharmacy pays

~$52.85 /30

$0.65 /g

Type

Active ingredient

CYCLOSPORINE

TACROLIMUS

Manufacturer

Novartis

Astellas

Dosage forms

Capsule, Solution

Capsule, Powder, Injectable

Drug class

Calcineurin Inhibitor Immunosuppressant

Boxed warning

Half-life

about 8.4 hours (range 5 to 18 hours)

—

Treats

Rheumatoid Arthritis, Focal Segmental Glomerulosclerosis, Systemic Lupus Erythematosus

Atopic Dermatitis, Graft Vs Host Disease

Frequently asked questions

Which is better-rated, Neoral or Prograf?

By our independent rating, Prograf scores higher — 3.6 vs 3.5 out of 5 for Neoral. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Neoral and Prograf?

Neoral contains Cyclosporine, while Prograf contains Tacrolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.