NAPROXEN vs ZORVOLEX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. NAPROXEN and ZORVOLEX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NAPROXEN	ZORVOLEX
Rating	72/100	New
Pharmacy pays	$0.06 /mL	$0.36 /mL
Type	RX	RX
Active ingredient	NAPROXEN	DICLOFENAC
Manufacturer	Hikma	Zyla
Dosage forms	Tablet	Capsule
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	Boxed warning	None
Half-life	about 12 to 17 hours	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Back Pain	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

naproxen zorvolex

Rating

72/100

New

Pharmacy pays

$0.06 /mL

$0.36 /mL

Type

Active ingredient

NAPROXEN

DICLOFENAC

Manufacturer

Hikma

Zyla

Dosage forms

Tablet

Capsule

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 12 to 17 hours

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is cheaper, Naproxen or Zorvolex?

Naproxen costs pharmacies less to acquire — about $0.06 vs $0.36 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Naproxen and Zorvolex?

Naproxen contains Naproxen, while Zorvolex contains Diclofenac — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.