Skip to content
ppharmaranks
Menu

NAPRELAN vs RUFEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. NAPRELAN and RUFEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

$0.06 /mL
$0.04 /mL

Type

RX
RX

Active ingredient

NAPROXEN SODIUM
IBUPROFEN

Manufacturer

Dosage forms

Tablet, extended release
Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug
Nonsteroidal Anti-Inflammatory Drug

Boxed warning

Half-life

about 12 to 17 hours
about 1.8 to 2.0 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Back Pain
Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Frequently asked questions

Which is cheaper, Naprelan or Rufen?

Rufen costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Naprelan and Rufen?

Naprelan contains Naproxen Sodium, while Rufen contains Ibuprofen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.