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NALOXONE vs ORLAAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. NALOXONE and ORLAAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

naloxoneorlaam

Rating

72/100
70/100

Pharmacy pays

$6.27 /mL
—

Type

RX
RX

Active ingredient

NALOXONE HYDROCHLORIDE
LEVOMETHADYL ACETATE HYDROCHLORIDE

Manufacturer

Hikma
Roxane

Dosage forms

Injectable
—

Drug class

Opioid Antagonist
—

Boxed warning

None
None

Half-life

30 to 81 minutes (mean 64 ± 12 minutes)
—

Treats

Opioid-Related Disorders, Respiration Disorders, Septic Shock
Opioid-Related Disorders

Frequently asked questions

Which is better-rated, Naloxone or Orlaam?

By our independent rating, Naloxone scores higher — 3.6 vs 3.5 out of 5 for Orlaam. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Naloxone and Orlaam?

Naloxone contains Naloxone Hydrochloride, while Orlaam contains Levomethadyl Acetate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.