NALOXONE vs NALTREXONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. NALOXONE and NALTREXONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NALOXONE	NALTREXONE
Rating	72/100	56/100
Pharmacy pays	$4.41 /mL	~$36.35 /30
Type	RX	RX
Active ingredient	NALOXONE HYDROCHLORIDE	NALTREXONE
Manufacturer	Hikma	Teva
Dosage forms	Injectable	Kit
Drug class	Opioid Antagonist	Opioid Antagonist
Boxed warning	None	None
Half-life	30 to 81 minutes (mean 64 ± 12 minutes)	—
Treats	Opioid-Related Disorders, Respiration Disorders, Septic Shock	Alcoholism, Opioid-Related Disorders, Drug Overdose

naloxone naltrexone

Rating

72/100

56/100

Pharmacy pays

$4.41 /mL

~$36.35 /30

Type

Active ingredient

NALOXONE HYDROCHLORIDE

NALTREXONE

Manufacturer

Hikma

Teva

Dosage forms

Injectable

Kit

Drug class

Opioid Antagonist

Boxed warning

None

Half-life

30 to 81 minutes (mean 64 ± 12 minutes)

—

Treats

Opioid-Related Disorders, Respiration Disorders, Septic Shock

Alcoholism, Opioid-Related Disorders, Drug Overdose

Frequently asked questions

Which is better-rated, Naloxone or Naltrexone?

By our independent rating, Naloxone scores higher — 3.6 vs 2.8 out of 5 for Naltrexone. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Naloxone and Naltrexone?

Naloxone contains Naloxone Hydrochloride, while Naltrexone contains Naltrexone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.