NABUMETONE vs PENNSAID

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. NABUMETONE and PENNSAID are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	NABUMETONE	PENNSAID
Rating	68/100	New
Pharmacy pays	~$4.00 /30	$0.36 /mL
Type	RX	RX
Active ingredient	NABUMETONE	DICLOFENAC SODIUM
Manufacturer	Aurobindo Pharma Ltd	Horizon
Dosage forms	Tablet	Solution
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	—	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Rheumatoid Arthritis, Inflammation, Osteoarthritis	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

nabumetone pennsaid

Rating

68/100

New

Pharmacy pays

~$4.00 /30

$0.36 /mL

Type

Active ingredient

NABUMETONE

DICLOFENAC SODIUM

Manufacturer

Aurobindo Pharma Ltd

Horizon

Dosage forms

Tablet

Solution

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

—

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Rheumatoid Arthritis, Inflammation, Osteoarthritis

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

What is the difference between Nabumetone and Pennsaid?

Nabumetone contains Nabumetone, while Pennsaid contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.