MYSOLINE vs ZIAC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. MYSOLINE and ZIAC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	ZIAC
Rating	74/100	New
Pharmacy pays	~$2.89 /30	~$5.34 /30
Type	RX	RX
Active ingredient	PRIMIDONE	BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE
Manufacturer	Valeant Pharm Intl	Teva Branded Pharm
Dosage forms	Tablet	Tablet
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	—	about 6 to 15 hours (the label reports a range, not a single number)
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	—

mysoline ziac

Rating

74/100

New

Pharmacy pays

~$2.89 /30

~$5.34 /30

Type

Active ingredient

PRIMIDONE

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE

Manufacturer

Valeant Pharm Intl

Teva Branded Pharm

Dosage forms

Tablet

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

—

about 6 to 15 hours (the label reports a range, not a single number)

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

—

Frequently asked questions

Which is cheaper, Mysoline or Ziac?

Mysoline costs pharmacies less to acquire — about $2.89 vs $5.34 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Ziac?

Mysoline contains Primidone, while Ziac contains Bisoprolol Fumarate and Hydrochlorothiazide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.