MYSOLINE vs TRANDATE HCT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. MYSOLINE and TRANDATE HCT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	TRANDATE HCT
Rating	74/100	72/100
Pharmacy pays	~$2.89 /30	~$0.91 /30
Type	RX	RX
Active ingredient	PRIMIDONE	HYDROCHLOROTHIAZIDE AND LABETALOL HYDROCHLORIDE
Manufacturer	Valeant Pharm Intl	Glaxosmithkline
Dosage forms	Tablet	Tablet
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	—	about 6 to 15 hours (the label reports a range, not a single number)
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	—

mysoline trandate hct

Rating

74/100

72/100

Pharmacy pays

~$2.89 /30

~$0.91 /30

Type

Active ingredient

PRIMIDONE

HYDROCHLOROTHIAZIDE AND LABETALOL HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl

Glaxosmithkline

Dosage forms

Tablet

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

—

about 6 to 15 hours (the label reports a range, not a single number)

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

—

Frequently asked questions

Which is better-rated, Mysoline or Trandate Hct?

By our independent rating, Mysoline scores higher — 3.7 vs 3.6 out of 5 for Trandate Hct. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mysoline or Trandate Hct?

Trandate Hct costs pharmacies less to acquire — about $0.91 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Trandate Hct?

Mysoline contains Primidone, while Trandate Hct contains Hydrochlorothiazide and Labetalol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.