MYSOLINE vs SYNALGOS-DC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. MYSOLINE and SYNALGOS-DC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	SYNALGOS-DC
Rating	74/100	62/100
Pharmacy pays	~$2.89 /30	~$0.78 /30
Type	RX	RX
Active ingredient	PRIMIDONE	ASPIRIN AND CAFFEINE AND DIHYDROCODEINE BITARTRATE
Manufacturer	Valeant Pharm Intl	Sun Pharm Industries
Dosage forms	Tablet	Capsule
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	—	about 20 minutes (the label also states 0.33 hours) for aspirin itself
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	—

mysoline synalgos-dc

Rating

74/100

62/100

Pharmacy pays

~$2.89 /30

~$0.78 /30

Type

Active ingredient

PRIMIDONE

ASPIRIN AND CAFFEINE AND DIHYDROCODEINE BITARTRATE

Manufacturer

Valeant Pharm Intl

Sun Pharm Industries

Dosage forms

Tablet

Capsule

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

—

about 20 minutes (the label also states 0.33 hours) for aspirin itself

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

—

Frequently asked questions

Which is better-rated, Mysoline or Synalgos-Dc?

By our independent rating, Mysoline scores higher — 3.7 vs 3.1 out of 5 for Synalgos-Dc. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mysoline or Synalgos-Dc?

Synalgos-Dc costs pharmacies less to acquire — about $0.78 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Synalgos-Dc?

Mysoline contains Primidone, while Synalgos-Dc contains Aspirin and Caffeine and Dihydrocodeine Bitartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.