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MYSOLINE vs QSYMIA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 11, 2026·How we rate

Possible drug interaction. MYSOLINE and QSYMIA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

74/100
70/100

Pharmacy pays

~$2.89 /30
~$2.49 /30

Type

RX
RX

Active ingredient

PRIMIDONE
PHENTERMINE HYDROCHLORIDE AND TOPIRAMATE

Dosage forms

Tablet
Capsule, extended release

Drug class

Anti-Epileptic Agent
—

Boxed warning

None
None

Half-life

—
about 21 hours

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor
—

Frequently asked questions

Which is better-rated, Mysoline or Qsymia?

By our independent rating, Mysoline scores higher — 3.7 vs 3.5 out of 5 for Qsymia. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mysoline or Qsymia?

Qsymia costs pharmacies less to acquire — about $2.49 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Qsymia?

Mysoline contains Primidone, while Qsymia contains Phentermine Hydrochloride and Topiramate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.