MYSOLINE vs POLYTRIM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. MYSOLINE and POLYTRIM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	POLYTRIM
Rating	74/100	72/100
Pharmacy pays	~$2.89 /30	—
Type	RX	RX
Active ingredient	PRIMIDONE	POLYMYXIN B SULFATE AND TRIMETHOPRIM SULFATE
Manufacturer	Valeant Pharm Intl	Allergan
Dosage forms	Tablet	Drops
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	—	about 8 to 10 hours
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	—

mysoline polytrim

Rating

74/100

72/100

Pharmacy pays

~$2.89 /30

—

Type

Active ingredient

PRIMIDONE

POLYMYXIN B SULFATE AND TRIMETHOPRIM SULFATE

Manufacturer

Valeant Pharm Intl

Allergan

Dosage forms

Tablet

Drops

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

—

about 8 to 10 hours

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

—

Frequently asked questions

Which is better-rated, Mysoline or Polytrim?

By our independent rating, Mysoline scores higher — 3.7 vs 3.6 out of 5 for Polytrim. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Mysoline and Polytrim?

Mysoline contains Primidone, while Polytrim contains Polymyxin B Sulfate and Trimethoprim Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.