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MYSOLINE vs PHENERGAN W/ CODEINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. MYSOLINE and PHENERGAN W/ CODEINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

74/100
72/100

Pharmacy pays

~$2.89 /30
~$20.54 /30

Type

RX
RX

Active ingredient

PRIMIDONE
CODEINE PHOSPHATE AND PROMETHAZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE

Dosage forms

Tablet
Syrup

Drug class

Anti-Epileptic Agent
—

Boxed warning

None
None

Half-life

—
about 9 to 16 hours

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor
—

Frequently asked questions

Which is better-rated, Mysoline or Phenergan W/ Codeine?

By our independent rating, Mysoline scores higher — 3.7 vs 3.6 out of 5 for Phenergan W/ Codeine. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mysoline or Phenergan W/ Codeine?

Mysoline costs pharmacies less to acquire — about $2.89 vs $20.54 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Phenergan W/ Codeine?

Mysoline contains Primidone, while Phenergan W/ Codeine contains Codeine Phosphate and Promethazine Hydrochloride and Phenylephrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.