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MYSOLINE vs PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. MYSOLINE and PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

mysolineperphenazine and amitriptyline hydrochloride

Rating

74/100
62/100

Pharmacy pays

~$2.89 /30
~$2.80 /30

Type

RX
RX

Active ingredient

PRIMIDONE
AMITRIPTYLINE HYDROCHLORIDE AND PERPHENAZINE

Manufacturer

Valeant Pharm Intl
Sun Pharm Industries

Dosage forms

Tablet
Tablet

Drug class

Anti-Epileptic Agent
—

Boxed warning

None
None

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor
—

Frequently asked questions

Which is better-rated, Mysoline or Perphenazine and Amitriptyline Hydrochloride?

By our independent rating, Mysoline scores higher — 3.7 vs 3.1 out of 5 for Perphenazine and Amitriptyline Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mysoline or Perphenazine and Amitriptyline Hydrochloride?

Perphenazine and Amitriptyline Hydrochloride costs pharmacies less to acquire — about $2.80 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Perphenazine and Amitriptyline Hydrochloride?

Mysoline contains Primidone, while Perphenazine and Amitriptyline Hydrochloride contains Amitriptyline Hydrochloride and Perphenazine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.