MYSOLINE vs NORGESIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. MYSOLINE and NORGESIC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	NORGESIC
Rating	74/100	New
Pharmacy pays	~$2.89 /30	~$0.78 /30
Type	RX	RX
Active ingredient	PRIMIDONE	ASPIRIN AND CAFFEINE AND ORPHENADRINE CITRATE
Manufacturer	Valeant Pharm Intl	Bausch
Dosage forms	Tablet	Tablet
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	—	about 20 minutes (the label also states 0.33 hours) for aspirin itself
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	—

mysoline norgesic

Rating

74/100

New

Pharmacy pays

~$2.89 /30

~$0.78 /30

Type

Active ingredient

PRIMIDONE

ASPIRIN AND CAFFEINE AND ORPHENADRINE CITRATE

Manufacturer

Valeant Pharm Intl

Bausch

Dosage forms

Tablet

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

—

about 20 minutes (the label also states 0.33 hours) for aspirin itself

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

—

Frequently asked questions

Which is cheaper, Mysoline or Norgesic?

Norgesic costs pharmacies less to acquire — about $0.78 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Norgesic?

Mysoline contains Primidone, while Norgesic contains Aspirin and Caffeine and Orphenadrine Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.