MOTRIN MIGRAINE PAIN vs RELAFEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. MOTRIN MIGRAINE PAIN and RELAFEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MOTRIN MIGRAINE PAIN	RELAFEN
Rating	70/100	New
Pharmacy pays	$0.04 /mL	~$4.00 /30
Type	RX	RX
Active ingredient	IBUPROFEN	NABUMETONE
Manufacturer	Kenvue Brands	Smithkline Beecham
Dosage forms	Tablet	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 1.8 to 2.0 hours	—
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis	Rheumatoid Arthritis, Inflammation, Osteoarthritis

motrin migraine pain relafen

Rating

70/100

New

Pharmacy pays

$0.04 /mL

~$4.00 /30

Type

Active ingredient

IBUPROFEN

NABUMETONE

Manufacturer

Kenvue Brands

Smithkline Beecham

Dosage forms

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 1.8 to 2.0 hours

—

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Rheumatoid Arthritis, Inflammation, Osteoarthritis

Frequently asked questions

What is the difference between Motrin Migraine Pain and Relafen?

Motrin Migraine Pain contains Ibuprofen, while Relafen contains Nabumetone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.