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MOTRIN MIGRAINE PAIN vs NAPRELAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. MOTRIN MIGRAINE PAIN and NAPRELAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

$0.04 /mL
$0.06 /mL

Type

RX
RX

Active ingredient

IBUPROFEN
NAPROXEN SODIUM

Dosage forms

Tablet
Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug
Nonsteroidal Anti-Inflammatory Drug

Boxed warning

Half-life

about 1.8 to 2.0 hours
about 12 to 17 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis
Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

Frequently asked questions

Which is cheaper, Motrin Migraine Pain or Naprelan?

Motrin Migraine Pain costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Motrin Migraine Pain and Naprelan?

Motrin Migraine Pain contains Ibuprofen, while Naprelan contains Naproxen Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.