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MORPHINE SULFATE vs OXYCODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. MORPHINE SULFATE and OXYCODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

$2.61 /mL
$0.08 /mL

Type

RX
RX

Active ingredient

MORPHINE SULFATE
OXYCODONE HYDROCHLORIDE

Dosage forms

Tablet, Tablet, extended release
Solution, Tablet, Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 2 hours
about 3.5 to 4 hours

Treats

Dyspnea, Intractable Pain
Postoperative Pain

Frequently asked questions

Which is cheaper, Morphine Sulfate or Oxycodone Hydrochloride?

Oxycodone Hydrochloride costs pharmacies less to acquire — about $0.08 vs $2.61 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Morphine Sulfate and Oxycodone Hydrochloride?

Morphine Sulfate contains Morphine Sulfate, while Oxycodone Hydrochloride contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.