MONISTAT vs SPECTAZOLE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. MONISTAT and SPECTAZOLE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MONISTAT	SPECTAZOLE
Rating	70/100	70/100
Pharmacy pays	$0.12 /g	$0.36 /g
Type	RX	RX
Active ingredient	MICONAZOLE	ECONAZOLE NITRATE
Manufacturer	Janssen Pharms	Alvogen
Dosage forms	Injectable	Topical
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	None
Treats	Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis	Cutaneous Candidiasis, Tinea Pedis, Tinea Versicolor

monistat spectazole

Rating

70/100

Pharmacy pays

$0.12 /g

$0.36 /g

Type

Active ingredient

MICONAZOLE

ECONAZOLE NITRATE

Manufacturer

Janssen Pharms

Alvogen

Dosage forms

Injectable

Topical

Drug class

Azole Antifungal

Boxed warning

None

Treats

Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis

Cutaneous Candidiasis, Tinea Pedis, Tinea Versicolor

Frequently asked questions

Which is better-rated, Monistat or Spectazole?

Monistat and Spectazole are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Monistat or Spectazole?

Monistat costs pharmacies less to acquire — about $0.12 vs $0.36 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Monistat and Spectazole?

Monistat contains Miconazole, while Spectazole contains Econazole Nitrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.