MONISTAT-DERM vs TOLSURA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. MONISTAT-DERM and TOLSURA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MONISTAT-DERM	TOLSURA
Rating	70/100	72/100
Pharmacy pays	—	$0.85 /mL
Type	RX	RX
Active ingredient	MICONAZOLE NITRATE	ITRACONAZOLE
Manufacturer	Insight Pharms	Mayne Pharma
Dosage forms	Topical	Capsule
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	Boxed warning
Half-life	—	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.
Treats	Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

monistat-derm tolsura

Rating

70/100

72/100

Pharmacy pays

—

$0.85 /mL

Type

Active ingredient

MICONAZOLE NITRATE

ITRACONAZOLE

Manufacturer

Insight Pharms

Mayne Pharma

Dosage forms

Topical

Capsule

Drug class

Azole Antifungal

Boxed warning

None

Boxed warning

Half-life

—

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

Treats

Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

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Frequently asked questions

Which is better-rated, Monistat-Derm or Tolsura?

By our independent rating, Tolsura scores higher — 3.6 vs 3.5 out of 5 for Monistat-Derm. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Monistat-Derm and Tolsura?

Monistat-Derm contains Miconazole Nitrate, while Tolsura contains Itraconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.