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MIDOL LIQUID GELS vs RUFEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Rating

70/100
70/100

Pharmacy pays

$0.04 /mL
$0.04 /mL

Type

OTC
RX

Active ingredient

IBUPROFEN
IBUPROFEN

Manufacturer

Dosage forms

Capsule
Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug
Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None
None

Half-life

about 1.8 to 2.0 hours
about 1.8 to 2.0 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis
Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is better-rated, Midol Liquid Gels or Rufen?

Midol Liquid Gels and Rufen are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Midol Liquid Gels or Rufen?

Pharmacies pay about the same to acquire either one — roughly $0.04 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Midol Liquid Gels and Rufen?

Both Midol Liquid Gels and Rufen share the active ingredient Ibuprofen, but Midol Liquid Gels is sold as OTC and Rufen as RX.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.