MIDAZOLAM HYDROCHLORIDE vs XANAX XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. MIDAZOLAM HYDROCHLORIDE and XANAX XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MIDAZOLAM HYDROCHLORIDE	XANAX XR
Rating	64/100	New
Pharmacy pays	$0.45 /mL	~$0.76 /30
Type	RX	RX
Active ingredient	MIDAZOLAM HYDROCHLORIDE	ALPRAZOLAM
Manufacturer	Fresenius Kabi USA	Upjohn
Dosage forms	Injectable, Syrup	Tablet, extended release
Drug class	Benzodiazepine	Benzodiazepine
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 11 hours (mean 11.2 hours; range roughly 6 to 27 hours) in healthy adults
Treats	Anxiety Disorders, Psychomotor Agitation, Status Epilepticus	Agoraphobia, Depressive Disorder, Panic Disorder

midazolam hydrochloride xanax xr

Rating

64/100

New

Pharmacy pays

$0.45 /mL

~$0.76 /30

Type

Active ingredient

MIDAZOLAM HYDROCHLORIDE

ALPRAZOLAM

Manufacturer

Fresenius Kabi USA

Upjohn

Dosage forms

Injectable, Syrup

Tablet, extended release

Drug class

Benzodiazepine

Boxed warning

Half-life

—

about 11 hours (mean 11.2 hours; range roughly 6 to 27 hours) in healthy adults

Treats

Anxiety Disorders, Psychomotor Agitation, Status Epilepticus

Agoraphobia, Depressive Disorder, Panic Disorder

Frequently asked questions

What is the difference between Midazolam Hydrochloride and Xanax XR?

Midazolam Hydrochloride contains Midazolam Hydrochloride, while Xanax XR contains Alprazolam — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.