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MEXILETINE HYDROCHLORIDE vs TIKOSYN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. MEXILETINE HYDROCHLORIDE and TIKOSYN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
60/100

Pharmacy pays

~$8.44 /30
~$5.80 /30

Type

RX
RX

Active ingredient

MEXILETINE HYDROCHLORIDE
DOFETILIDE

Dosage forms

Capsule
Capsule

Drug class

Antiarrhythmic
Antiarrhythmic

Boxed warning

Treats

Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes
Atrial Fibrillation, Atrial Flutter

Frequently asked questions

Which is better-rated, Mexiletine Hydrochloride or Tikosyn?

By our independent rating, Mexiletine Hydrochloride scores higher — 3.5 vs 3.0 out of 5 for Tikosyn. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mexiletine Hydrochloride or Tikosyn?

Tikosyn costs pharmacies less to acquire — about $5.80 vs $8.44 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mexiletine Hydrochloride and Tikosyn?

Mexiletine Hydrochloride contains Mexiletine Hydrochloride, while Tikosyn contains Dofetilide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.