MEXILETINE HYDROCHLORIDE vs RYTHMOL SR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. MEXILETINE HYDROCHLORIDE and RYTHMOL SR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MEXILETINE HYDROCHLORIDE	RYTHMOL SR
Rating	70/100	70/100
Pharmacy pays	~$8.44 /30	~$10.51 /30
Type	RX	RX
Active ingredient	MEXILETINE HYDROCHLORIDE	PROPAFENONE HYDROCHLORIDE
Manufacturer	Macleods Pharms Ltd	Glaxosmithkline
Dosage forms	Capsule	Capsule, extended release
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	None	None
Half-life	—	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers
Treats	Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes	Atrial Fibrillation, Supraventricular Tachycardia

mexiletine hydrochloride rythmol sr

Rating

70/100

Pharmacy pays

~$8.44 /30

~$10.51 /30

Type

Active ingredient

MEXILETINE HYDROCHLORIDE

PROPAFENONE HYDROCHLORIDE

Manufacturer

Macleods Pharms Ltd

Glaxosmithkline

Dosage forms

Capsule

Capsule, extended release

Drug class

Antiarrhythmic

Boxed warning

None

Half-life

—

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes

Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is better-rated, Mexiletine Hydrochloride or Rythmol SR?

Mexiletine Hydrochloride and Rythmol SR are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Mexiletine Hydrochloride or Rythmol SR?

Mexiletine Hydrochloride costs pharmacies less to acquire — about $8.44 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mexiletine Hydrochloride and Rythmol SR?

Mexiletine Hydrochloride contains Mexiletine Hydrochloride, while Rythmol SR contains Propafenone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.