MEXILETINE HYDROCHLORIDE vs PROPAFENONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. MEXILETINE HYDROCHLORIDE and PROPAFENONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MEXILETINE HYDROCHLORIDE	PROPAFENONE HYDROCHLORIDE
Rating	70/100	72/100
Pharmacy pays	~$8.44 /30	~$10.51 /30
Type	RX	RX
Active ingredient	MEXILETINE HYDROCHLORIDE	PROPAFENONE HYDROCHLORIDE
Manufacturer	Macleods Pharms Ltd	Rising
Dosage forms	Capsule	Capsule, extended release, Tablet
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	None	Boxed warning
Half-life	—	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers
Treats	Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes	Atrial Fibrillation, Supraventricular Tachycardia

mexiletine hydrochloride propafenone hydrochloride

Rating

70/100

72/100

Pharmacy pays

~$8.44 /30

~$10.51 /30

Type

Active ingredient

MEXILETINE HYDROCHLORIDE

PROPAFENONE HYDROCHLORIDE

Manufacturer

Macleods Pharms Ltd

Rising

Dosage forms

Capsule

Capsule, extended release, Tablet

Drug class

Antiarrhythmic

Boxed warning

None

Boxed warning

Half-life

—

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes

Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is better-rated, Mexiletine Hydrochloride or Propafenone Hydrochloride?

By our independent rating, Propafenone Hydrochloride scores higher — 3.6 vs 3.5 out of 5 for Mexiletine Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mexiletine Hydrochloride or Propafenone Hydrochloride?

Mexiletine Hydrochloride costs pharmacies less to acquire — about $8.44 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mexiletine Hydrochloride and Propafenone Hydrochloride?

Mexiletine Hydrochloride contains Mexiletine Hydrochloride, while Propafenone Hydrochloride contains Propafenone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.