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METHYLPREDNISOLONE vs ZYFLO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. METHYLPREDNISOLONE and ZYFLO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
72/100

Pharmacy pays

~$30.69 /30
~$61.97 /30

Type

RX
RX

Active ingredient

METHYLPREDNISOLONE
ZILEUTON

Manufacturer

Dosage forms

Tablet
Tablet

Drug class

Corticosteroid
5-Lipoxygenase Inhibitor

Boxed warning

None
None

Treats

Adrenal Insufficiency, Asthma, Berylliosis
Asthma

Get methylprednisolonehigher-rated option

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Frequently asked questions

Which is better-rated, Methylprednisolone or Zyflo?

Methylprednisolone and Zyflo are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Methylprednisolone or Zyflo?

Methylprednisolone costs pharmacies less to acquire — about $30.69 vs $61.97 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Methylprednisolone and Zyflo?

Methylprednisolone contains Methylprednisolone, while Zyflo contains Zileuton — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.