METHYLPHENIDATE HYDROCHLORIDE vs VYVANSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. METHYLPHENIDATE HYDROCHLORIDE and VYVANSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	METHYLPHENIDATE HYDROCHLORIDE	VYVANSE
Rating	New	New
Pharmacy pays	~$18.94 /30	—
Type	RX	RX
Active ingredient	METHYLPHENIDATE HYDROCHLORIDE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Alkem Labs Ltd	Takeda Pharms USA
Dosage forms	Capsule, extended release, Solution, Tablet, Tablet, chewable, Tablet, extended release	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	None	Boxed warning
Half-life	about 2.7 hours	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Binge Drinking

methylphenidate hydrochloride vyvanse

Rating

New

Pharmacy pays

~$18.94 /30

—

Type

Active ingredient

METHYLPHENIDATE HYDROCHLORIDE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Alkem Labs Ltd

Takeda Pharms USA

Dosage forms

Capsule, extended release, Solution, Tablet, Tablet, chewable, Tablet, extended release

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

None

Boxed warning

Half-life

about 2.7 hours

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

What is the difference between Methylphenidate Hydrochloride and Vyvanse?

Methylphenidate Hydrochloride contains Methylphenidate Hydrochloride, while Vyvanse contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.