METHYLIN vs XELSTRYM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. METHYLIN and XELSTRYM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	METHYLIN	XELSTRYM
Rating	70/100	68/100
Pharmacy pays	~$18.94 /30	~$29.94 /30
Type	RX	RX
Active ingredient	METHYLPHENIDATE HYDROCHLORIDE	DEXTROAMPHETAMINE
Manufacturer	Specgx LLC	Noven Pharms Inc
Dosage forms	Solution	Patch, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2.7 hours	—
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Narcolepsy

methylin xelstrym

Rating

70/100

68/100

Pharmacy pays

~$18.94 /30

~$29.94 /30

Type

Active ingredient

METHYLPHENIDATE HYDROCHLORIDE

DEXTROAMPHETAMINE

Manufacturer

Specgx LLC

Noven Pharms Inc

Dosage forms

Solution

Patch, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 2.7 hours

—

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Frequently asked questions

Which is better-rated, Methylin or Xelstrym?

By our independent rating, Methylin scores higher — 3.5 vs 3.4 out of 5 for Xelstrym. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Methylin or Xelstrym?

Methylin costs pharmacies less to acquire — about $18.94 vs $29.94 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Methylin and Xelstrym?

Methylin contains Methylphenidate Hydrochloride, while Xelstrym contains Dextroamphetamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.