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METHOTREXATE PRESERVATIVE FREE vs OTREXUP

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. METHOTREXATE PRESERVATIVE FREE and OTREXUP are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

methotrexate preservative freeotrexup

Rating

54/100
New

Pharmacy pays

~$4.92 /30
~$4.92 /30

Type

RX
RX

Active ingredient

METHOTREXATE SODIUM
METHOTREXATE

Manufacturer

Hospira
Assertio Speclty

Dosage forms

Injectable
Injectable

Drug class

Folate Analog Metabolic Inhibitor
Folate Analog Metabolic Inhibitor

Boxed warning

Boxed warning
Boxed warning

Half-life

about 3 to 10 hours
about 3 to 10 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms
Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

Frequently asked questions

Which is cheaper, Methotrexate Preservative Free or Otrexup?

Pharmacies pay about the same to acquire either one — roughly $4.92 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Methotrexate Preservative Free and Otrexup?

Methotrexate Preservative Free contains Methotrexate Sodium, while Otrexup contains Methotrexate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.