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METHOTREXATE PRESERVATIVE FREE vs METHOTREXATE SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Rating

54/100
New

Pharmacy pays

~$4.92 /30
~$4.92 /30

Type

RX
RX

Active ingredient

METHOTREXATE SODIUM
METHOTREXATE SODIUM

Manufacturer

Dosage forms

Injectable
Tablet

Drug class

Folate Analog Metabolic Inhibitor
Folate Analog Metabolic Inhibitor

Boxed warning

Half-life

about 3 to 10 hours
about 3 to 10 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms
Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

Frequently asked questions

Which is cheaper, Methotrexate Preservative Free or Methotrexate Sodium?

Pharmacies pay about the same to acquire either one — roughly $4.92 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Methotrexate Preservative Free and Methotrexate Sodium?

Both Methotrexate Preservative Free and Methotrexate Sodium share the active ingredient Methotrexate Sodium.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.