METHOTREXATE LPF vs METHOTREXATE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Attribute	METHOTREXATE LPF	METHOTREXATE PRESERVATIVE FREE
Rating	54/100	54/100
Pharmacy pays	~$4.92 /30	~$4.92 /30
Type	RX	RX
Active ingredient	METHOTREXATE SODIUM	METHOTREXATE SODIUM
Manufacturer	Hospira	Hospira
Dosage forms	Injectable	Injectable
Drug class	Folate Analog Metabolic Inhibitor	Folate Analog Metabolic Inhibitor
Boxed warning	Boxed warning	Boxed warning
Half-life	about 3 to 10 hours	about 3 to 10 hours
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms	Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

methotrexate lpf methotrexate preservative free

Rating

54/100

Pharmacy pays

~$4.92 /30

Type

Active ingredient

METHOTREXATE SODIUM

Manufacturer

Hospira

Dosage forms

Injectable

Drug class

Folate Analog Metabolic Inhibitor

Boxed warning

Half-life

about 3 to 10 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

Frequently asked questions

Which is better-rated, Methotrexate Lpf or Methotrexate Preservative Free?

Methotrexate Lpf and Methotrexate Preservative Free are tied at 2.7 out of 5 by our independent rating.

Which is cheaper, Methotrexate Lpf or Methotrexate Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $4.92 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Methotrexate Lpf and Methotrexate Preservative Free?

Both Methotrexate Lpf and Methotrexate Preservative Free share the active ingredient Methotrexate Sodium.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.