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METHADOSE vs SUBLIMAZE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. METHADOSE and SUBLIMAZE PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
72/100

Pharmacy pays

$0.18 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

METHADONE HYDROCHLORIDE
FENTANYL CITRATE

Manufacturer

Dosage forms

Injectable

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Opioid-Related Disorders, Intractable Pain
Pain

Frequently asked questions

Which is better-rated, Methadose or Sublimaze Preservative Free?

By our independent rating, Sublimaze Preservative Free scores higher — 3.6 vs 3.5 out of 5 for Methadose. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Methadose or Sublimaze Preservative Free?

Methadose costs pharmacies less to acquire — about $0.18 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Methadose and Sublimaze Preservative Free?

Methadose contains Methadone Hydrochloride, while Sublimaze Preservative Free contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.