METHADOSE vs OXYCODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. METHADOSE and OXYCODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	METHADOSE	OXYCODONE HYDROCHLORIDE
Rating	70/100	70/100
Pharmacy pays	$0.18 /mL	$0.08 /mL
Type	RX	RX
Active ingredient	METHADONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Specgx LLC	Vistapharm LLC
Dosage forms	—	Solution, Tablet, Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 8 to 59 hours (terminal/elimination half-life; a very wide range)	about 3.5 to 4 hours
Treats	Opioid-Related Disorders, Intractable Pain	Postoperative Pain

methadose oxycodone hydrochloride

Rating

70/100

Pharmacy pays

$0.18 /mL

$0.08 /mL

Type

Active ingredient

METHADONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Specgx LLC

Vistapharm LLC

Dosage forms

—

Solution, Tablet, Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

about 3.5 to 4 hours

Treats

Opioid-Related Disorders, Intractable Pain

Postoperative Pain

Frequently asked questions

Which is better-rated, Methadose or Oxycodone Hydrochloride?

Methadose and Oxycodone Hydrochloride are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Methadose or Oxycodone Hydrochloride?

Oxycodone Hydrochloride costs pharmacies less to acquire — about $0.08 vs $0.18 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Methadose and Oxycodone Hydrochloride?

Methadose contains Methadone Hydrochloride, while Oxycodone Hydrochloride contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.