METHADOSE vs OPANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. METHADOSE and OPANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	METHADOSE	OPANA
Rating	70/100	72/100
Pharmacy pays	$0.18 /mL	~$36.74 /30
Type	RX	RX
Active ingredient	METHADONE HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Specgx LLC	Endo Pharms
Dosage forms	—	Tablet, Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 8 to 59 hours (terminal/elimination half-life; a very wide range)	—
Treats	Opioid-Related Disorders, Intractable Pain	Pain

methadose opana

Rating

70/100

72/100

Pharmacy pays

$0.18 /mL

~$36.74 /30

Type

Active ingredient

METHADONE HYDROCHLORIDE

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Specgx LLC

Endo Pharms

Dosage forms

—

Tablet, Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

—

Treats

Opioid-Related Disorders, Intractable Pain

Pain

Frequently asked questions

Which is better-rated, Methadose or Opana?

By our independent rating, Opana scores higher — 3.6 vs 3.5 out of 5 for Methadose. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Methadose and Opana?

Methadose contains Methadone Hydrochloride, while Opana contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.