Skip to content
ppharmaranks
Menu

METHADONE HYDROCHLORIDE vs MORPHINE SULFATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. METHADONE HYDROCHLORIDE and MORPHINE SULFATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

$0.18 /mL
$2.61 /mL

Type

RX
RX

Active ingredient

METHADONE HYDROCHLORIDE
MORPHINE SULFATE

Dosage forms

Injectable, Solution, Tablet
Tablet, Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)
about 2 hours

Treats

Opioid-Related Disorders, Intractable Pain
Dyspnea, Intractable Pain

Frequently asked questions

Which is cheaper, Methadone Hydrochloride or Morphine Sulfate?

Methadone Hydrochloride costs pharmacies less to acquire — about $0.18 vs $2.61 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Methadone Hydrochloride and Morphine Sulfate?

Methadone Hydrochloride contains Methadone Hydrochloride, while Morphine Sulfate contains Morphine Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.