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METAXALONE vs SKELAXIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Rating

70/100
New

Pharmacy pays

~$11.97 /30
~$11.97 /30

Type

RX
RX

Active ingredient

METAXALONE
METAXALONE

Dosage forms

Tablet
Tablet

Drug class

Muscle Relaxant
Muscle Relaxant

Boxed warning

None
None

Half-life

about 9 hours (terminal half-life 9.0 ± 4.8 hours after a 400 mg oral dose, fasted; ~8 hours at 800 mg)
about 9 hours (terminal half-life 9.0 ± 4.8 hours after a 400 mg oral dose, fasted; ~8 hours at 800 mg)

Treats

Muscle Cramp, Muscle Rigidity, Muscle Spasticity
Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Frequently asked questions

Which is cheaper, Metaxalone or Skelaxin?

Pharmacies pay about the same to acquire either one — roughly $11.97 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Metaxalone and Skelaxin?

Both Metaxalone and Skelaxin share the active ingredient Metaxalone.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.